Drug interactions
Nirogacestat + Ribociclib
Severity: Major
Nirogacestat and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may increase nirogacestat exposure by inhibiting CYP3A4. This may worsen diarrhea, hepatotoxicity and other adverse effects.
What this interaction means in plain words
Nirogacestat and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nirogacestat belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4 metabolism of nirogacestat.
What to do
Avoid if possible; if used, reduce the nirogacestat dose as advised in labeling for moderate CYP3A inhibitors. Monitor liver tests and diarrhea.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Nirogacestat
Frequently asked questions
Can I take Nirogacestat with Ribociclib?
MediHelp rates the interaction as major. Nirogacestat and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib may increase nirogacestat exposure by inhibiting CYP3A4. This may worsen diarrhea, hepatotoxicity and other adverse effects.
How serious is the interaction between Nirogacestat and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, reduce the nirogacestat dose as advised in labeling for moderate CYP3A inhibitors. Monitor liver tests and diarrhea.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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