Drug interactions
Nisoldipine + Prazosin
Severity: Moderate
Nisoldipine and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prazosin and the dihydropyridine calcium channel blocker nisoldipine both lower blood pressure by different routes. Combined use can cause additive hypotension, reflex tachycardia, dizziness and peripheral edema.
What this interaction means in plain words
Nisoldipine and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nisoldipine belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 blockade and calcium channel blockade.
What to do
Monitor blood pressure and heart rate, and titrate doses gradually. Counsel patients to rise slowly, particularly after first doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nisoldipine and Prazosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Prazosin?
MediHelp rates the interaction as moderate. Nisoldipine and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prazosin and the dihydropyridine calcium channel blocker nisoldipine both lower blood pressure by different routes. Combined use can cause additive hypotension, reflex tachycardia, dizziness and peripheral edema.
How serious is the interaction between Nisoldipine and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and titrate doses gradually. Counsel patients to rise slowly, particularly after first doses.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
