Drug interactions
Nisoldipine + Propranolol
Severity: Moderate
Nisoldipine and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a beta-blocker with a dihydropyridine calcium channel blocker is often useful, but it can increase blood pressure lowering and occasionally cause hypotension or heart failure in susceptible patients. Propranolol exposure may also rise slightly.
What this interaction means in plain words
Nisoldipine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nisoldipine belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive vasodilatory and negative inotropic effects, with possible reduction in propranolol first-pass clearance.
What to do
Monitor blood pressure and heart rate, titrate nisoldipine gradually, and watch for heart failure symptoms in patients with impaired ventricular function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Propranolol?
MediHelp rates the interaction as moderate. Nisoldipine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a beta-blocker with a dihydropyridine calcium channel blocker is often useful, but it can increase blood pressure lowering and occasionally cause hypotension or heart failure in susceptible patients. Propranolol exposure may also rise slightly.
How serious is the interaction between Nisoldipine and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, titrate nisoldipine gradually, and watch for heart failure symptoms in patients with impaired ventricular function.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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