Drug interactions
Nisoldipine + Sodium nitroprusside
Severity: Moderate
Nisoldipine and Sodium nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nisoldipine is a dihydropyridine calcium channel blocker that lowers blood pressure and may amplify the effect of nitroprusside. Marked hypotension may occur.
What this interaction means in plain words
Nisoldipine and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nisoldipine belongs to Cardiovascular; Sodium nitroprusside belongs to Cardiovascular.
Why it happens
Additive vasodilation through calcium channel blockade and nitric oxide mediated smooth muscle relaxation.
What to do
Monitor blood pressure continuously and titrate nitroprusside to the target, using lower doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sodium nitroprusside
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Sodium nitroprusside?
MediHelp rates the interaction as moderate. Nisoldipine and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nisoldipine is a dihydropyridine calcium channel blocker that lowers blood pressure and may amplify the effect of nitroprusside. Marked hypotension may occur.
How serious is the interaction between Nisoldipine and Sodium nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously and titrate nitroprusside to the target, using lower doses if needed.
What other medicines interact with Sodium nitroprusside?
MediHelp also lists interactions of Sodium nitroprusside with, for example, Avanafil, Nitric oxide, Sildenafil. The full list is on the Sodium nitroprusside page.
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