Drug interactions
Nitrendipine + Voriconazole
Severity: Moderate
Nitrendipine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrendipine is cleared by CYP3A4, and voriconazole can raise its concentrations. This may cause excessive vasodilation with hypotension, headache, flushing and peripheral edema.
What this interaction means in plain words
Nitrendipine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by voriconazole reduces first-pass and systemic metabolism of nitrendipine.
What to do
Monitor blood pressure and heart rate and reduce the nitrendipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Nitrendipine with Voriconazole?
MediHelp rates the interaction as moderate. Nitrendipine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrendipine is cleared by CYP3A4, and voriconazole can raise its concentrations. This may cause excessive vasodilation with hypotension, headache, flushing and peripheral edema.
How serious is the interaction between Nitrendipine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and reduce the nitrendipine dose if hypotension or edema occurs.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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