Drug interactions
Nitrofurantoin + Sofosbuvir / velpatasvir
Severity: Minor
Nitrofurantoin and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits BCRP and may raise exposure to BCRP substrates. Nitrofurantoin has been described as a BCRP substrate, but the clinical significance is unclear and likely small.
What this interaction means in plain words
Nitrofurantoin and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Velpatasvir inhibition of intestinal BCRP efflux may increase nitrofurantoin absorption.
What to do
No routine dose change is needed. Monitor for nitrofurantoin adverse effects such as nausea, and for pulmonary or neurologic symptoms with prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Nitrofurantoin with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Nitrofurantoin and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits BCRP and may raise exposure to BCRP substrates. Nitrofurantoin has been described as a BCRP substrate, but the clinical significance is unclear and likely small.
How serious is the interaction between Nitrofurantoin and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for nitrofurantoin adverse effects such as nausea, and for pulmonary or neurologic symptoms with prolonged use.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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