Drug interactions
Nitrofurantoin + Tafamidis meglumine
Severity: Minor
Nitrofurantoin and Tafamidis meglumine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis meglumine inhibits BCRP in vitro and may increase exposure to BCRP substrates. Nitrofurantoin is a possible BCRP substrate, so levels may rise modestly, though clinical impact is not established.
What this interaction means in plain words
Nitrofurantoin and Tafamidis meglumine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Tafamidis inhibition of BCRP efflux transport may increase nitrofurantoin exposure.
What to do
No routine adjustment is needed. Monitor for nitrofurantoin adverse effects, particularly in patients with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Nitrofurantoin with Tafamidis meglumine?
MediHelp rates the interaction as minor. Nitrofurantoin and Tafamidis meglumine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tafamidis meglumine inhibits BCRP in vitro and may increase exposure to BCRP substrates. Nitrofurantoin is a possible BCRP substrate, so levels may rise modestly, though clinical impact is not established.
How serious is the interaction between Nitrofurantoin and Tafamidis meglumine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for nitrofurantoin adverse effects, particularly in patients with reduced renal function.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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