Drug interactions
Nitrofurantoin + Typhoid vaccine live
Severity: Moderate
Nitrofurantoin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrofurantoin has some activity against enteric Gram-negative bacteria and could theoretically reduce survival of the oral live typhoid vaccine strain. Evidence of an effect is lacking.
What this interaction means in plain words
Nitrofurantoin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible antibacterial effect on the live attenuated Salmonella vaccine strain, reducing immunogenicity.
What to do
Give the oral live vaccine at least 24 hours after the last nitrofurantoin dose, or use the inactivated injectable vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Nitrofurantoin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Nitrofurantoin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrofurantoin has some activity against enteric Gram-negative bacteria and could theoretically reduce survival of the oral live typhoid vaccine strain. Evidence of an effect is lacking.
How serious is the interaction between Nitrofurantoin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the oral live vaccine at least 24 hours after the last nitrofurantoin dose, or use the inactivated injectable vaccine.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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