Drug interactions
Nitrofurantoin + Valoctocogene roxaparvovec
Severity: Moderate
Nitrofurantoin and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec commonly causes raised liver enzymes, and nitrofurantoin can cause hepatotoxicity. Combining them may increase the risk of liver injury and complicate interpretation of enzyme rises, which may also reduce gene therapy effect.
What this interaction means in plain words
Nitrofurantoin and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nitrofurantoin belongs to Anti Bacterial; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxic potential from the gene therapy and nitrofurantoin.
What to do
Monitor ALT and other liver tests closely after gene therapy while nitrofurantoin is used. Prefer a non-hepatotoxic antibiotic where practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitrofurantoin
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Nitrofurantoin with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Nitrofurantoin and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec commonly causes raised liver enzymes, and nitrofurantoin can cause hepatotoxicity. Combining them may increase the risk of liver injury and complicate interpretation of enzyme rises, which may also reduce gene therapy effect.
How serious is the interaction between Nitrofurantoin and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT and other liver tests closely after gene therapy while nitrofurantoin is used. Prefer a non-hepatotoxic antibiotic where practical.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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