Drug interactions
Nivolumab + Oxaliplatin
Severity: Minor
Nivolumab and Oxaliplatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nivolumab enhances immune activity rather than suppressing it, so an additive immunosuppressive effect with oxaliplatin is not accurate. The combination is used in practice, with overlapping adverse effects such as hematologic and gastrointestinal toxicity to watch for.
What this interaction means in plain words
Nivolumab and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nivolumab belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
No true pharmacokinetic interaction; overlapping toxicities occur through distinct mechanisms.
What to do
Use per approved regimens and monitor blood counts, liver function and immune-related adverse events.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Nivolumab
- Nivolumab + Thalidomide Major
- Dexamethasone-tobramycin + Nivolumab Moderate
- Dexamethasone + Nivolumab Moderate
- Efgartigimod / hyaluronidase sc + Nivolumab Moderate
- Efgartigimod alfa + Nivolumab Moderate
- Nivolumab + Ponesimod Moderate
Frequently asked questions
Can I take Nivolumab with Oxaliplatin?
MediHelp rates the interaction as minor. Nivolumab and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nivolumab enhances immune activity rather than suppressing it, so an additive immunosuppressive effect with oxaliplatin is not accurate. The combination is used in practice, with overlapping adverse effects such as hematologic and gastrointestinal toxicity to watch for.
How serious is the interaction between Nivolumab and Oxaliplatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use per approved regimens and monitor blood counts, liver function and immune-related adverse events.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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