Drug interactions
Nizatidine + Sotorasib
Severity: Moderate
Nizatidine and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib solubility is pH-dependent, and acid-reducing drugs can reduce its exposure; the effect was greater with proton pump inhibitors, whereas H2 blockers have modest effects. Efficacy could be reduced.
What this interaction means in plain words
Nizatidine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nizatidine belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Nizatidine raises gastric pH, reducing the pH-dependent dissolution and absorption of sotorasib.
What to do
Take sotorasib 4 hours before or 10 hours after the H2 blocker, or use a locally acting antacid instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Nizatidine with Sotorasib?
MediHelp rates the interaction as moderate. Nizatidine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib solubility is pH-dependent, and acid-reducing drugs can reduce its exposure; the effect was greater with proton pump inhibitors, whereas H2 blockers have modest effects. Efficacy could be reduced.
How serious is the interaction between Nizatidine and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take sotorasib 4 hours before or 10 hours after the H2 blocker, or use a locally acting antacid instead.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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