Drug interactions
Norepinephrine + Perphenazine
Severity: Moderate
Norepinephrine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has alpha-adrenergic blocking activity that can blunt the pressor response to norepinephrine. Higher infusion doses may be needed to maintain blood pressure, and both drugs can influence cardiac rhythm. The effect is variable.
What this interaction means in plain words
Norepinephrine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-1 adrenergic antagonism by perphenazine opposes the vasoconstrictor action of norepinephrine.
What to do
Titrate norepinephrine to blood pressure response with continuous hemodynamic and ECG monitoring. Be prepared to use higher doses than usual in patients taking perphenazine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Norepinephrine with Perphenazine?
MediHelp rates the interaction as moderate. Norepinephrine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine has alpha-adrenergic blocking activity that can blunt the pressor response to norepinephrine. Higher infusion doses may be needed to maintain blood pressure, and both drugs can influence cardiac rhythm. The effect is variable.
How serious is the interaction between Norepinephrine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate norepinephrine to blood pressure response with continuous hemodynamic and ECG monitoring. Be prepared to use higher doses than usual in patients taking perphenazine.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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