Drug interactions
Norethindrone + Ribociclib
Severity: Minor
Norethindrone and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norethindrone is partly metabolized by CYP3A4, so ribociclib may modestly raise its levels. The clinical effect is small, and hormonal contraception is generally not advised during breast cancer treatment.
What this interaction means in plain words
Norethindrone and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ribociclib inhibits CYP3A4, slightly reducing norethindrone metabolism.
What to do
No dose change is needed. Advise non-hormonal contraception in premenopausal patients on ribociclib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Norethindrone with Ribociclib?
MediHelp rates the interaction as minor. Norethindrone and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Norethindrone is partly metabolized by CYP3A4, so ribociclib may modestly raise its levels. The clinical effect is small, and hormonal contraception is generally not advised during breast cancer treatment.
How serious is the interaction between Norethindrone and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Advise non-hormonal contraception in premenopausal patients on ribociclib.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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