Drug interactions
Norethindrone + Voriconazole
Severity: Minor
Norethindrone and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases norethindrone exposure, as shown in studies with ethinylestradiol and norethindrone combinations. Hormone-related adverse effects may become more frequent, while contraceptive efficacy is not reduced.
What this interaction means in plain words
Norethindrone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of norethindrone.
What to do
No dose change is generally needed. Monitor for hormonal adverse effects such as nausea, headache and breast tenderness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Norethindrone and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Norethindrone with Voriconazole?
MediHelp rates the interaction as minor. Norethindrone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole increases norethindrone exposure, as shown in studies with ethinylestradiol and norethindrone combinations. Hormone-related adverse effects may become more frequent, while contraceptive efficacy is not reduced.
How serious is the interaction between Norethindrone and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for hormonal adverse effects such as nausea, headache and breast tenderness.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
