Drug interactions
Norethisterone + Rifampin
Severity: Major
Norethisterone and Rifampin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces hepatic metabolism and reduces norethisterone exposure. Contraceptive failure and irregular bleeding have been reported with rifamycins and hormonal contraceptives.
What this interaction means in plain words
Norethisterone and Rifampin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Rifampin induces CYP3A4 and other enzymes, increasing the clearance of norethisterone.
What to do
Use a nonhormonal method such as a copper IUD, or add barrier methods, during rifampin treatment. Continue backup protection for about 4 weeks after stopping rifampin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Frequently asked questions
Can I take Norethisterone with Rifampin?
MediHelp rates the interaction as major. Norethisterone and Rifampin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampin strongly induces hepatic metabolism and reduces norethisterone exposure. Contraceptive failure and irregular bleeding have been reported with rifamycins and hormonal contraceptives.
How serious is the interaction between Norethisterone and Rifampin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a nonhormonal method such as a copper IUD, or add barrier methods, during rifampin treatment. Continue backup protection for about 4 weeks after stopping rifampin.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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