Drug interactions
Norgestrel + Sertraline
Severity: Minor
Norgestrel and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is a weak CYP3A4 inhibitor and is unlikely to change norgestrel exposure meaningfully. No clinically relevant loss of contraceptive efficacy or excess hormonal effect is expected.
What this interaction means in plain words
Norgestrel and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Norgestrel belongs to Endocrine; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline could marginally reduce progestin metabolism.
What to do
No adjustment is required. Counsel the patient to report breakthrough bleeding or hormonal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Norgestrel with Sertraline?
MediHelp rates the interaction as minor. Norgestrel and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline is a weak CYP3A4 inhibitor and is unlikely to change norgestrel exposure meaningfully. No clinically relevant loss of contraceptive efficacy or excess hormonal effect is expected.
How serious is the interaction between Norgestrel and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required. Counsel the patient to report breakthrough bleeding or hormonal adverse effects.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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