Drug interactions
Norgestrel + Verapamil
Severity: Minor
Norgestrel and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise norgestrel concentrations by inhibiting its metabolism. This could increase progestogenic adverse effects, though contraceptive efficacy is not expected to be reduced.
What this interaction means in plain words
Norgestrel and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Norgestrel belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, reducing the metabolism of norgestrel.
What to do
No routine change is needed. Watch for progestogen-related side effects such as breakthrough bleeding, headache or mood change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Norgestrel with Verapamil?
MediHelp rates the interaction as minor. Norgestrel and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may raise norgestrel concentrations by inhibiting its metabolism. This could increase progestogenic adverse effects, though contraceptive efficacy is not expected to be reduced.
How serious is the interaction between Norgestrel and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for progestogen-related side effects such as breakthrough bleeding, headache or mood change.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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