Drug interactions
Nortriptyline + Oliceridine
Severity: Moderate
Nortriptyline and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can depress the central nervous system, and nortriptyline adds anticholinergic effects that compound opioid-induced constipation and urinary retention. Serotonergic effects are possible but are less established for oliceridine than for some other opioids.
What this interaction means in plain words
Nortriptyline and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression plus additive anticholinergic effects on gut and bladder, with a possible minor serotonergic contribution.
What to do
Titrate oliceridine to the lowest effective dose and monitor sedation, respiratory rate, bowel function and urinary output. Use a bowel regimen and watch for serotonin toxicity signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Nortriptyline with Oliceridine?
MediHelp rates the interaction as moderate. Nortriptyline and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can depress the central nervous system, and nortriptyline adds anticholinergic effects that compound opioid-induced constipation and urinary retention. Serotonergic effects are possible but are less established for oliceridine than for some other opioids.
How serious is the interaction between Nortriptyline and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine to the lowest effective dose and monitor sedation, respiratory rate, bowel function and urinary output. Use a bowel regimen and watch for serotonin toxicity signs.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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