Drug interactions
Nortriptyline + Orphenadrin
Severity: Moderate
Nortriptyline and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity and cause sedation. Combined use can produce dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia, with greater risk in older adults.
What this interaction means in plain words
Nortriptyline and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive muscarinic receptor blockade and central nervous system depression.
What to do
Monitor for anticholinergic toxicity and sedation, and avoid the combination in older patients or those with glaucoma or urinary retention. Reduce doses or choose alternatives if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Orphenadrin?
MediHelp rates the interaction as moderate. Nortriptyline and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity and cause sedation. Combined use can produce dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia, with greater risk in older adults.
How serious is the interaction between Nortriptyline and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, and avoid the combination in older patients or those with glaucoma or urinary retention. Reduce doses or choose alternatives if symptoms appear.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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