Drug interactions
Nortriptyline + Procarbazine
Severity: Contraindicated
Nortriptyline and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting properties, so with nortriptyline there is a risk of serotonin syndrome or hypertensive episodes.
What this interaction means in plain words
Nortriptyline and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nortriptyline belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition plus tricyclic monoamine reuptake blockade increases serotonergic and adrenergic activity.
What to do
Avoid the combination; observe a washout of about 14 days after stopping procarbazine before nortriptyline. Use a different antidepressant during procarbazine therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Nortriptyline with Procarbazine?
MediHelp rates the interaction as contraindicated. Nortriptyline and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has weak MAO-inhibiting properties, so with nortriptyline there is a risk of serotonin syndrome or hypertensive episodes.
How serious is the interaction between Nortriptyline and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; observe a washout of about 14 days after stopping procarbazine before nortriptyline. Use a different antidepressant during procarbazine therapy.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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