Drug interactions
Nortriptyline + Tolazamide
Severity: Minor
Nortriptyline and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can change glycemic control, and with a sulfonylurea this may shift blood glucose, with hypoglycemia reported in some cases. The effect is generally small and unpredictable.
What this interaction means in plain words
Nortriptyline and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nortriptyline belongs to Central Nervous System; Tolazamide belongs to Endocrine.
Why it happens
Possible pharmacodynamic effects of tricyclics on glucose handling and insulin sensitivity, not firmly established.
What to do
Monitor blood glucose when starting or stopping nortriptyline and adjust the sulfonylurea if hypoglycemia or hyperglycemia appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Nortriptyline with Tolazamide?
MediHelp rates the interaction as minor. Nortriptyline and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants can change glycemic control, and with a sulfonylurea this may shift blood glucose, with hypoglycemia reported in some cases. The effect is generally small and unpredictable.
How serious is the interaction between Nortriptyline and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping nortriptyline and adjust the sulfonylurea if hypoglycemia or hyperglycemia appears.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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