Drug interactions
Nortriptyline + Umeclidinium-vilanterol
Severity: Major
Nortriptyline and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as nortriptyline can prolong the QT interval and potentiate the cardiovascular effects of beta-2 agonists. Together with vilanterol, this may cause tachycardia, arrhythmias, and blood pressure changes.
What this interaction means in plain words
Nortriptyline and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nortriptyline belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with tricyclic-mediated potentiation of adrenergic cardiovascular effects.
What to do
Use only with close monitoring of heart rate, blood pressure and ECG, particularly in patients with cardiac disease. Consider alternatives when possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Nortriptyline and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants such as nortriptyline can prolong the QT interval and potentiate the cardiovascular effects of beta-2 agonists. Together with vilanterol, this may cause tachycardia, arrhythmias, and blood pressure changes.
How serious is the interaction between Nortriptyline and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with close monitoring of heart rate, blood pressure and ECG, particularly in patients with cardiac disease. Consider alternatives when possible.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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