Drug interactions
Obinutuzumab + Tisagenlecleucel
Severity: Major
Obinutuzumab and Tisagenlecleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obinutuzumab depletes B cells and can cause neutropenia and serious infections. Tisagenlecleucel causes B-cell aplasia, cytopenias and hypogammaglobulinemia. Together they may increase infection risk.
What this interaction means in plain words
Obinutuzumab and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Obinutuzumab belongs to Oncology; Tisagenlecleucel belongs to Oncology.
Why it happens
Additive B-cell depletion and immunosuppression.
What to do
Avoid concurrent use and follow the CAR T product's guidance on washout of prior therapy. Monitor for infection and cytopenias and consider immunoglobulin replacement.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Obinutuzumab
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Obinutuzumab with Tisagenlecleucel?
MediHelp rates the interaction as major. Obinutuzumab and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Obinutuzumab depletes B cells and can cause neutropenia and serious infections. Tisagenlecleucel causes B-cell aplasia, cytopenias and hypogammaglobulinemia. Together they may increase infection risk.
How serious is the interaction between Obinutuzumab and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and follow the CAR T product's guidance on washout of prior therapy. Monitor for infection and cytopenias and consider immunoglobulin replacement.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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