Drug interactions
Octreotide + Oxaliplatin
Severity: Moderate
Octreotide and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin can prolong the QT interval and cause electrolyte losses, and octreotide may add QT prolongation and bradycardia. Together they may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Octreotide and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT prolongation, with oxaliplatin-related hypokalemia and hypomagnesemia as contributors.
What to do
Check baseline ECG, potassium and magnesium, and monitor during treatment. Correct electrolytes promptly and avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Octreotide with Oxaliplatin?
MediHelp rates the interaction as moderate. Octreotide and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin can prolong the QT interval and cause electrolyte losses, and octreotide may add QT prolongation and bradycardia. Together they may increase the risk of ventricular arrhythmia.
How serious is the interaction between Octreotide and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG, potassium and magnesium, and monitor during treatment. Correct electrolytes promptly and avoid additional QT-prolonging drugs.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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