Drug interactions
Octreotide + Perphenazine
Severity: Moderate
Octreotide and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and conduction abnormalities including QT prolongation, and perphenazine also prolongs QT. The additive effect may increase arrhythmia risk, particularly in patients with other risk factors.
What this interaction means in plain words
Octreotide and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia.
What to do
Obtain a baseline ECG and monitor heart rate and QTc, correcting electrolytes. Consider an alternative if QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Perphenazine?
MediHelp rates the interaction as moderate. Octreotide and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and conduction abnormalities including QT prolongation, and perphenazine also prolongs QT. The additive effect may increase arrhythmia risk, particularly in patients with other risk factors.
How serious is the interaction between Octreotide and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and QTc, correcting electrolytes. Consider an alternative if QTc becomes significantly prolonged.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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