Drug interactions
Octreotide + Rilpivirine
Severity: Moderate
Octreotide and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QT interval, and octreotide may contribute QT effects and bradycardia. The combination may modestly increase the risk of arrhythmia, particularly with other risk factors.
What this interaction means in plain words
Octreotide and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and monitor periodically. Correct electrolyte abnormalities and avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Octreotide with Rilpivirine?
MediHelp rates the interaction as moderate. Octreotide and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at supratherapeutic doses prolongs the QT interval, and octreotide may contribute QT effects and bradycardia. The combination may modestly increase the risk of arrhythmia, particularly with other risk factors.
How serious is the interaction between Octreotide and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and monitor periodically. Correct electrolyte abnormalities and avoid adding further QT-prolonging drugs.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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