Drug interactions
Octreotide + Tacrolimus
Severity: Moderate
Octreotide and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval, and octreotide may add to this through QT effects and bradycardia. Octreotide may also alter glucose handling, relevant in transplant patients prone to tacrolimus-related diabetes.
What this interaction means in plain words
Octreotide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and electrolytes, particularly with other QT-prolonging drugs or cardiac disease. Monitor tacrolimus trough levels and blood glucose as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Octreotide with Tacrolimus?
MediHelp rates the interaction as moderate. Octreotide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval, and octreotide may add to this through QT effects and bradycardia. Octreotide may also alter glucose handling, relevant in transplant patients prone to tacrolimus-related diabetes.
How serious is the interaction between Octreotide and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, particularly with other QT-prolonging drugs or cardiac disease. Monitor tacrolimus trough levels and blood glucose as clinically indicated.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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