Drug interactions
Octreotide + Trimethoprim
Severity: Minor
Octreotide and Trimethoprim: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QTc prolongation, so combined use may add to arrhythmia risk. The clinical significance is likely small in patients without other risk factors.
What this interaction means in plain words
Octreotide and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Octreotide belongs to Endocrine; Trimethoprim belongs to Anti Bacterial.
Why it happens
Possible additive QT prolongation; the effect of trimethoprim is weak and not firmly established.
What to do
No routine action is needed in low-risk patients. Check ECG and electrolytes if the patient has cardiac disease or takes other QT-prolonging drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Octreotide
Other interactions of Trimethoprim
Frequently asked questions
Can I take Octreotide with Trimethoprim?
MediHelp rates the interaction as minor. Octreotide and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been associated with QTc prolongation, so combined use may add to arrhythmia risk. The clinical significance is likely small in patients without other risk factors.
How serious is the interaction between Octreotide and Trimethoprim?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed in low-risk patients. Check ECG and electrolytes if the patient has cardiac disease or takes other QT-prolonging drugs.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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