Drug interactions
Octreotide + Voriconazole
Severity: Moderate
Octreotide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and octreotide can also cause bradycardia, which adds to the risk of torsades de pointes. The risk is higher with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Octreotide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QT prolongation, with octreotide-related bradycardia as a further contributor.
What to do
Obtain a baseline ECG and monitor QTc during co-therapy. Correct potassium and magnesium before and during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Voriconazole?
MediHelp rates the interaction as moderate. Octreotide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and octreotide can also cause bradycardia, which adds to the risk of torsades de pointes. The risk is higher with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Octreotide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc during co-therapy. Correct potassium and magnesium before and during treatment.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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