Drug interactions
Ofatumumab sc + Ribociclib
Severity: Moderate
Ofatumumab sc and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and ribociclib causes neutropenia, so the two together may increase susceptibility to infection. The combination has not been well studied.
What this interaction means in plain words
Ofatumumab sc and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and ribociclib-induced neutropenia.
What to do
Check blood counts and screen for active infection before ofatumumab doses, and monitor for infection during combined therapy. Hold ribociclib per labeling for significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ofatumumab sc with Ribociclib?
MediHelp rates the interaction as moderate. Ofatumumab sc and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and ribociclib causes neutropenia, so the two together may increase susceptibility to infection. The combination has not been well studied.
How serious is the interaction between Ofatumumab sc and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood counts and screen for active infection before ofatumumab doses, and monitor for infection during combined therapy. Hold ribociclib per labeling for significant neutropenia.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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