Drug interactions
Ofatumumab sc + Sarilumab
Severity: Moderate
Ofatumumab sc and Sarilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and sarilumab blocks IL-6 signaling, so the combination may produce additive immunosuppression. This can increase the risk of serious infections.
What this interaction means in plain words
Ofatumumab sc and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression through B-cell depletion and IL-6 receptor blockade.
What to do
Monitor for infections and neutrophil counts, and avoid starting both without a clear indication. Hold treatment if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sarilumab
Frequently asked questions
Can I take Ofatumumab sc with Sarilumab?
MediHelp rates the interaction as moderate. Ofatumumab sc and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and sarilumab blocks IL-6 signaling, so the combination may produce additive immunosuppression. This can increase the risk of serious infections.
How serious is the interaction between Ofatumumab sc and Sarilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infections and neutrophil counts, and avoid starting both without a clear indication. Hold treatment if a serious infection develops.
What other medicines interact with Sarilumab?
MediHelp also lists interactions of Sarilumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Dengue vaccine. The full list is on the Sarilumab page.
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