Drug interactions
Ofatumumab sc + Sirolimus
Severity: Moderate
Ofatumumab sc and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and sirolimus suppresses T cell function, so together they may add to immunosuppression and raise the risk of infections. The risk may persist after either drug is stopped.
What this interaction means in plain words
Ofatumumab sc and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic immunosuppression.
What to do
Monitor for signs of infection and screen for hepatitis B and other relevant infections before treatment. Reassess the need for combination therapy if infections occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Ofatumumab sc with Sirolimus?
MediHelp rates the interaction as moderate. Ofatumumab sc and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and sirolimus suppresses T cell function, so together they may add to immunosuppression and raise the risk of infections. The risk may persist after either drug is stopped.
How serious is the interaction between Ofatumumab sc and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and screen for hepatitis B and other relevant infections before treatment. Reassess the need for combination therapy if infections occur.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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