Drug interactions
Ofatumumab sc + Tacrolimus
Severity: Moderate
Ofatumumab sc and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress immune function, so using them together may increase the risk of infections. The risk may persist after either drug is stopped.
What this interaction means in plain words
Ofatumumab sc and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion (ofatumumab) and calcineurin inhibition (tacrolimus).
What to do
Monitor for signs of infection and consider the combined immunosuppressive burden before starting ofatumumab. Screen for hepatitis B and other relevant infections beforehand.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Ofatumumab sc with Tacrolimus?
MediHelp rates the interaction as moderate. Ofatumumab sc and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress immune function, so using them together may increase the risk of infections. The risk may persist after either drug is stopped.
How serious is the interaction between Ofatumumab sc and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and consider the combined immunosuppressive burden before starting ofatumumab. Screen for hepatitis B and other relevant infections beforehand.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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