Drug interactions
Ofloxacin + Quetiapine
Severity: Moderate
Ofloxacin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so giving them together may raise the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia, or underlying heart disease.
What this interaction means in plain words
Ofloxacin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Quetiapine belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac potassium channels (hERG) leading to delayed ventricular repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Consider a non-QT-prolonging antibiotic in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Ofloxacin with Quetiapine?
MediHelp rates the interaction as moderate. Ofloxacin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so giving them together may raise the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia, or underlying heart disease.
How serious is the interaction between Ofloxacin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Consider a non-QT-prolonging antibiotic in patients with additional risk factors.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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