Drug interactions
Ofloxacin + Repaglinide
Severity: Moderate
Ofloxacin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients on glucose-lowering drugs. Combined with repaglinide, which stimulates insulin release, hypoglycemia may occur and can be severe.
What this interaction means in plain words
Ofloxacin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Repaglinide belongs to Endocrine.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release, adding to the insulin secretagogue effect of repaglinide.
What to do
Monitor blood glucose closely during and after the antibiotic course, and teach the patient to recognize hypoglycemia symptoms. Adjust the repaglinide dose if glucose control changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Ofloxacin with Repaglinide?
MediHelp rates the interaction as moderate. Ofloxacin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients on glucose-lowering drugs. Combined with repaglinide, which stimulates insulin release, hypoglycemia may occur and can be severe.
How serious is the interaction between Ofloxacin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and after the antibiotic course, and teach the patient to recognize hypoglycemia symptoms. Adjust the repaglinide dose if glucose control changes.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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