Drug interactions
Ofloxacin + Sulindac
Severity: Moderate
Ofloxacin and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones may increase the likelihood of CNS excitation and convulsions. The risk is greatest in patients with epilepsy, prior seizures, or other seizure risk factors.
What this interaction means in plain words
Ofloxacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Fluoroquinolones antagonize GABA-A receptors and NSAIDs may potentiate this effect, lowering seizure threshold.
What to do
Avoid the combination in patients with seizure disorders where possible. Otherwise monitor for tremor, agitation or seizures and consider a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Sulindac?
MediHelp rates the interaction as moderate. Ofloxacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs given with fluoroquinolones may increase the likelihood of CNS excitation and convulsions. The risk is greatest in patients with epilepsy, prior seizures, or other seizure risk factors.
How serious is the interaction between Ofloxacin and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure disorders where possible. Otherwise monitor for tremor, agitation or seizures and consider a non-NSAID analgesic.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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