Drug interactions
Ofloxacin + Tolazamide
Severity: Moderate
Ofloxacin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause significant hypoglycemia in patients taking sulfonylureas. Severe and prolonged hypoglycemia has been reported, particularly in elderly patients and those with renal impairment.
What this interaction means in plain words
Ofloxacin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Tolazamide belongs to Endocrine.
Why it happens
Fluoroquinolones enhance insulin release from beta cells, adding to sulfonylurea stimulation.
What to do
Monitor blood glucose closely during the antibiotic course and reduce the tolazamide dose if hypoglycemia occurs. Counsel patients on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Ofloxacin with Tolazamide?
MediHelp rates the interaction as moderate. Ofloxacin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause significant hypoglycemia in patients taking sulfonylureas. Severe and prolonged hypoglycemia has been reported, particularly in elderly patients and those with renal impairment.
How serious is the interaction between Ofloxacin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and reduce the tolazamide dose if hypoglycemia occurs. Counsel patients on hypoglycemia symptoms.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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