Drug interactions
Ofloxacin + Tolfenamic acid
Severity: Moderate
Ofloxacin and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can lower the seizure threshold, and concurrent NSAID use has been reported to increase this risk. Convulsions have occurred in some patients given this combination, particularly those with epilepsy or other predisposing factors.
What this interaction means in plain words
Ofloxacin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Fluoroquinolones antagonize GABA-A receptor binding, and NSAIDs may potentiate this effect, leading to CNS excitation.
What to do
Avoid the combination in patients with epilepsy, prior seizures or other CNS risk factors, and choose a different analgesic if possible. If used together, counsel the patient to report tremor, agitation or seizure activity promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ofloxacin and Tolfenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Ofloxacin with Tolfenamic acid?
MediHelp rates the interaction as moderate. Ofloxacin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can lower the seizure threshold, and concurrent NSAID use has been reported to increase this risk. Convulsions have occurred in some patients given this combination, particularly those with epilepsy or other predisposing factors.
How serious is the interaction between Ofloxacin and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with epilepsy, prior seizures or other CNS risk factors, and choose a different analgesic if possible. If used together, counsel the patient to report tremor, agitation or seizure activity promptly.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
