Drug interactions
Ofloxacin + Verapamil
Severity: Minor
Ofloxacin and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The interaction is theoretical, based on shared renal tubular secretion. Verapamil is cleared mainly by hepatic metabolism, so a clinically relevant change in exposure is unlikely.
What this interaction means in plain words
Ofloxacin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ofloxacin belongs to Anti Bacterial; Verapamil belongs to Cardiovascular.
Why it happens
Theoretical competition for renal tubular secretion; verapamil is mainly cleared hepatically, so any effect is probably negligible.
What to do
No specific action is required. Routine monitoring of heart rate and blood pressure is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Ofloxacin with Verapamil?
MediHelp rates the interaction as minor. Ofloxacin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The interaction is theoretical, based on shared renal tubular secretion. Verapamil is cleared mainly by hepatic metabolism, so a clinically relevant change in exposure is unlikely.
How serious is the interaction between Ofloxacin and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required. Routine monitoring of heart rate and blood pressure is sufficient.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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