Drug interactions
Ofloxacin + Warfarin
Severity: Moderate
Ofloxacin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones may raise the INR in patients on warfarin and increase bleeding risk. The response varies between patients, and infection itself can also alter anticoagulation.
What this interaction means in plain words
Ofloxacin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
The mechanism is not well established; possible effects include reduced vitamin K-producing gut flora and displacement of warfarin from protein binding.
What to do
Check the INR within several days of starting ofloxacin and again after stopping it. Adjust the warfarin dose based on the results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Ofloxacin with Warfarin?
MediHelp rates the interaction as moderate. Ofloxacin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones may raise the INR in patients on warfarin and increase bleeding risk. The response varies between patients, and infection itself can also alter anticoagulation.
How serious is the interaction between Ofloxacin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the INR within several days of starting ofloxacin and again after stopping it. Adjust the warfarin dose based on the results.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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