Drug interactions
Olanzapine + Osilodrostat
Severity: Moderate
Olanzapine and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them may increase the risk of torsades de pointes, particularly with electrolyte disturbance or heart disease. Olanzapine has a relatively low QT liability, which moderates the risk.
What this interaction means in plain words
Olanzapine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation through cardiac repolarisation effects.
What to do
Obtain a baseline ECG and repeat after starting or changing doses. Correct potassium and magnesium levels, and be careful with additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Osilodrostat
Frequently asked questions
Can I take Olanzapine with Osilodrostat?
MediHelp rates the interaction as moderate. Olanzapine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combining them may increase the risk of torsades de pointes, particularly with electrolyte disturbance or heart disease. Olanzapine has a relatively low QT liability, which moderates the risk.
How serious is the interaction between Olanzapine and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after starting or changing doses. Correct potassium and magnesium levels, and be careful with additional QT-prolonging drugs.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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