Drug interactions
Olanzapine + Osimertinib
Severity: Moderate
Olanzapine and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may raise the risk of ventricular arrhythmia, especially with other risk factors. Olanzapine's own effect on QT is small.
What this interaction means in plain words
Olanzapine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes periodically, correcting potassium and magnesium disturbances. Reassess therapy if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Osimertinib
Frequently asked questions
Can I take Olanzapine with Osimertinib?
MediHelp rates the interaction as moderate. Olanzapine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may raise the risk of ventricular arrhythmia, especially with other risk factors. Olanzapine's own effect on QT is small.
How serious is the interaction between Olanzapine and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically, correcting potassium and magnesium disturbances. Reassess therapy if the QTc becomes markedly prolonged.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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