Drug interactions
Olanzapine + Oxaliplatin
Severity: Moderate
Olanzapine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation and electrolyte loss, and olanzapine can add a small effect. Olanzapine is also frequently used as an antiemetic in oxaliplatin regimens.
What this interaction means in plain words
Olanzapine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT prolongation, aggravated by oxaliplatin-related hypokalaemia and hypomagnesaemia.
What to do
Monitor and replace potassium and magnesium, and obtain an ECG in patients with cardiac risk factors or other QT-prolonging drugs. The combination is generally acceptable with this monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Olanzapine with Oxaliplatin?
MediHelp rates the interaction as moderate. Olanzapine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation and electrolyte loss, and olanzapine can add a small effect. Olanzapine is also frequently used as an antiemetic in oxaliplatin regimens.
How serious is the interaction between Olanzapine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor and replace potassium and magnesium, and obtain an ECG in patients with cardiac risk factors or other QT-prolonging drugs. The combination is generally acceptable with this monitoring.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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