Drug interactions
Olanzapine + Papaverine
Severity: Minor
Olanzapine and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and hypotension, so combined use might increase drowsiness and dizziness. Documented clinical effects are limited.
What this interaction means in plain words
Olanzapine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olanzapine belongs to Central Nervous System; Papaverine belongs to Cardiovascular.
Why it happens
Possible additive CNS depressant and vasodilatory effects; not well characterised.
What to do
Monitor for sedation and orthostatic hypotension, particularly when starting treatment or in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Olanzapine with Papaverine?
MediHelp rates the interaction as minor. Olanzapine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause sedation and hypotension, so combined use might increase drowsiness and dizziness. Documented clinical effects are limited.
How serious is the interaction between Olanzapine and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, particularly when starting treatment or in older patients.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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