Drug interactions
Olanzapine + Ribociclib
Severity: Major
Olanzapine and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib causes dose-dependent QT prolongation, and olanzapine may add a small effect. The risk is greater with other QT-prolonging drugs or electrolyte abnormalities.
What this interaction means in plain words
Olanzapine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Olanzapine belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Obtain ECG and electrolytes before and during ribociclib therapy, and correct abnormalities. Interrupt or reduce ribociclib if QTc becomes prolonged, or choose a lower-risk antipsychotic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Olanzapine
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Olanzapine with Ribociclib?
MediHelp rates the interaction as major. Olanzapine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib causes dose-dependent QT prolongation, and olanzapine may add a small effect. The risk is greater with other QT-prolonging drugs or electrolyte abnormalities.
How serious is the interaction between Olanzapine and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and electrolytes before and during ribociclib therapy, and correct abnormalities. Interrupt or reduce ribociclib if QTc becomes prolonged, or choose a lower-risk antipsychotic.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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