Drug interactions
Olanzapine + Rilpivirine
Severity: Moderate
Olanzapine and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QT interval, and olanzapine has a modest QT-prolonging potential. Combined use may add to arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Olanzapine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Consider baseline and follow-up ECG in patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Olanzapine with Rilpivirine?
MediHelp rates the interaction as moderate. Olanzapine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at supratherapeutic doses prolongs the QT interval, and olanzapine has a modest QT-prolonging potential. Combined use may add to arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Olanzapine and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and follow-up ECG in patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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