Drug interactions
Olanzapine + Rosiglitazone
Severity: Moderate
Olanzapine and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can raise blood glucose and promote weight gain and insulin resistance, which may counteract the glucose-lowering effect of rosiglitazone. Glycemic control may deteriorate in patients with diabetes.
What this interaction means in plain words
Olanzapine and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Rosiglitazone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: olanzapine-related insulin resistance and metabolic effects oppose the insulin-sensitizing action of rosiglitazone.
What to do
Monitor fasting glucose and HbA1c after starting or changing olanzapine, and adjust antidiabetic therapy as needed. Also monitor weight and lipids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Olanzapine with Rosiglitazone?
MediHelp rates the interaction as moderate. Olanzapine and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can raise blood glucose and promote weight gain and insulin resistance, which may counteract the glucose-lowering effect of rosiglitazone. Glycemic control may deteriorate in patients with diabetes.
How serious is the interaction between Olanzapine and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting or changing olanzapine, and adjust antidiabetic therapy as needed. Also monitor weight and lipids.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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