Drug interactions
Olanzapine + Saxagliptin
Severity: Moderate
Olanzapine and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine may worsen glycemic control through weight gain and insulin resistance, reducing the effectiveness of saxagliptin. Patients with diabetes may need treatment adjustment.
What this interaction means in plain words
Olanzapine and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Saxagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: olanzapine-induced metabolic disturbance opposes the glucose-lowering effect of DPP-4 inhibition.
What to do
Monitor blood glucose and HbA1c regularly when olanzapine is started or its dose is changed. Intensify the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Olanzapine with Saxagliptin?
MediHelp rates the interaction as moderate. Olanzapine and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine may worsen glycemic control through weight gain and insulin resistance, reducing the effectiveness of saxagliptin. Patients with diabetes may need treatment adjustment.
How serious is the interaction between Olanzapine and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly when olanzapine is started or its dose is changed. Intensify the antidiabetic regimen if control worsens.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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