Drug interactions
Olanzapine + Selinexor
Severity: Moderate
Olanzapine and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue, and olanzapine can cause sedation and dizziness. Combined use may worsen neurological and cognitive adverse effects and increase fall risk.
What this interaction means in plain words
Olanzapine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive central nervous system effects; no pharmacokinetic mechanism established.
What to do
Monitor for dizziness, confusion and sedation, and counsel patients about fall risk and driving. Reduce doses or adjust therapy if neurological toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Olanzapine with Selinexor?
MediHelp rates the interaction as moderate. Olanzapine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue, and olanzapine can cause sedation and dizziness. Combined use may worsen neurological and cognitive adverse effects and increase fall risk.
How serious is the interaction between Olanzapine and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel patients about fall risk and driving. Reduce doses or adjust therapy if neurological toxicity develops.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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