Drug interactions
Olanzapine + Solifenacin
Severity: Moderate
Olanzapine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has anticholinergic properties, so combining it with solifenacin increases the risk of constipation, urinary retention, dry mouth, confusion and tachycardia. Both can affect QT interval modestly, and constipation can progress to ileus in vulnerable patients.
What this interaction means in plain words
Olanzapine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects and additive mild QT prolongation.
What to do
Monitor bowel function, urinary retention and cognition, particularly in older adults. Consider an ECG when other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Solifenacin?
MediHelp rates the interaction as moderate. Olanzapine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has anticholinergic properties, so combining it with solifenacin increases the risk of constipation, urinary retention, dry mouth, confusion and tachycardia. Both can affect QT interval modestly, and constipation can progress to ileus in vulnerable patients.
How serious is the interaction between Olanzapine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function, urinary retention and cognition, particularly in older adults. Consider an ECG when other QT risk factors are present.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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